One part of HBase Replication is that of turning on configs on the Server end to enable the feature. This can be done via the API exactly like Marcell described. The other part of replication configs is the peer configuration, but this is not doable via CM API as it is not a service-passed configuration, but more of a runtime one. You will need to use HBase's Java API (ReplicationAdmin class) directly for this: http://archive.cloudera.com/cdh5/cdh/5/hbase/apidocs/org/apache/hadoop/hbase/client/replication/ReplicationAdmin.html. To do this in Python, I'd guess you will need to use Jython or such. ... View more